Denis Noble
(1936-)
Denis Noble is a British physiologist and biologist who was at the University of Oxford from 1984 to 2004 and was appointed professor emeritus and co-director of computational physiology.
Noble's research focuses on using computer models of biological organs and organ systems to interpret function from the molecular level to the whole organism. Together with international collaborators, his team has used supercomputers to create the first virtual organ, the virtual heart.
With
James Shapiro in 2014, Noble established The Third Way of Evolution (TWE) project with James A. Shapiro which rejects natural selection as the primary cause of evolution and predicts that the entire framework of the modern synthesis of evolution will be replaced.
Noble has rejected natural selection as the primary mechanism of evolution, contrary to the longstanding consensus of evolutionary biologists, and calls for The Third Way of Evolution to replace the
Modern Synthesis.
Noble argues that from research in epigenetics, acquired characteristics can be inherited and in contrast to the modern synthesis, genetic change is "far from random" and not always gradual. He has also claimed that the central dogma of molecular biology has been broken as an "embodiment of the
Weismann Barrier", and a new synthesis will integrate research from physiology with evolutionary biology.
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